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Diana Mesa, RDN, LDN, CDCES, founder of En La Mesa Nutrition, agrees, adding that Berberine does have some similarities [to GLP-1 RA medications] in that it can trigger the pancreas to release insulin and helps make cells more sensitive to the effect of insulin, which is a characteristic similar to what Metformin [another prescription medication prescribed to treat type 2 diabetes and other off-label conditions] does. Still, she notes that its unclear whether or not Berberine has any appetite-suppressing effects like Ozempic and similar medications

Diabetes 61 , 197207 (2012)

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

Despite its recent rise, many claims related to berberines role in GLP-1 production have not been clinically validated