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Early integration of chemistry, manufacturing, and controls considerations into translational planning is therefore essential to avoid late-stage attrition

6.3 Clinical Symptoms That Should Prompt Assessment Patients on GLP-1 therapy should seek review if experiencing: Persistent fatigue Hair thinning beyond expected telogen shift Neurological symptoms (numbness, tingling) Muscle weakness Persistent vomiting Severe dietary restriction These symptoms are non-specific but warrant nutritional evaluation

Tirzepatide once weekly for the treatment of obesity. NEJM , 2022

P = 0.04), a main contributor to the reduction of 3-MACE composite endpoint (253)