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Description

Minimal Systemic Effects: Works primarily at the application site with limited whole-body exposure

Zaidi, N., Royaux, I., Swinnen, J

To achieve tHcy concentrations as low as possible ( C mutation in the MTRR gene creates an SF2/ASF binding exonic splicing enhancer, which leads to pseudoexon activation and causes the cblE type of homocystinuria

The difference is subtle and does not indicate any chemical change