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225 Administration of the PRMT4 inhibitor TP-064 in a mouse model of atherosclerotic cardiovascular disease can induce a decrease in monocyte tumor necrosis factor- (TNF-) secretion, downregulate the gene expression of the glycogen metabolism-related protein G6pc in the liver, and reduce plasma triglyceride levels, exerting regulatory effects from inflammatory and metabolic pathways

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Sleep deprivation also interferes with hunger-related hormonesinsulin, ghrelin and leptinleading to weight gain and insulin resistance, contributing to pre-diabetes and type 2 diabetes