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Histone deacetylase inhibitors (HDACi)s have gained attention for their ability to modulate protein transcription, and in the context of G6PD, have been shown to increase PPP flux by upregulating and downregulating G6PD expression in cancer cells [78,79]

Research in his lab is supported in part by CPRIT (RR160082) and the Welch foundation (I-194420180324)

Healthcare professionals are encouraged to report any suspected counterfeit medications

This HO-CO pathway has been recently proposed to be involved in the defence against oxidative stress and the deleterious effects of NO, since it removes the cytotoxic free heme, and produces some molecules with antioxidant and anti-inflammatory effects, such as biliverdin and CO [8, 3840]