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This metabolic reprogramming not only fulfills the energy demands required for the rapid proliferation of cancer cells but also results in the accumulation of numerous toxic by-products (e.g., methylglyoxal [MG], L-2-hydroxyglutaric acid, and glutaryl coenzyme A) ( It is worth noting that the effect of MG exhibits a prominent dose-dependent dual effect known as hormesis: at low concentrations, MG can induce malignant transformation of normal cells and promote carcinogenesis

doi: 10.1111/j.1365-2044.2007.05370.x