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A critical consideration is that rapid weight loss from any causewhether through medication, surgery, or lifestyle modificationis associated with bone density reduction, making it challenging to isolate the independent effect of GLP-1 medications from the effect of weight loss itself

And the mRNA expression levels of SIRT1, PGC-1, and PEPCK in the liver of the mice were significantly increased

Its also approved for people who are obese, defined by a BMI of 30 or greater, and are looking for a treatment to aid in weight management

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