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TNF-a) involve in apoptosis pathway and a possible inducer to P53 parenchymal cells, it also the factor which is responsible for the damage of the parenchyma of the lung due to the failed remodeling process (Yadegari et al

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In pregnant, obese, insulin-resistant, and diabetic humans, the number of single/small clusters of insulin + cells and bihormone-expressing cells, as well as the proportion of insulin + cells, within ducts has been observed to increase, suggesting that neogenesis may be the main mechanism in adult humans[7,8,71]