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These platforms are highly engineered medical devices studied under controlled conditions, often in early-stage clinical trials

In the Phase 2 trial published in the New England Journal of Medicine, participants receiving the highest dose of retatrutide (12mg weekly) achieved a mean body weight reduction of 24.2% over 48 weeks

The most frequently reported adverse effects of GLP-1 receptor agonists are gastrointestinal in nature, including nausea, vomiting, diarrhea, constipation, and abdominal discomfort

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