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PMID: 36598468

Septerna has developed a native complex platform that can reconstitute the GLP-1 receptor within an artificial lipid bilayer, complexed with combinations of drug and internal cell signalling molecules, which replicates the dynamics of the signalling process at scale

Certain complications, such as gallstones or pancreatitis (inflamed pancreas), are rare but possible

The MHRA-approved dosing schedule involves gradual titration, starting at 0.25 mg once weekly for 4 weeks, then increasing to 0.5 mg once weekly, with further increases to 1 mg or 2 mg possible after at least 4 weeks at each dose level