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Maridebart cafraglutide (a monthly GLP-1 in trials) addresses this by using an IgG scaffold to harness the natural FcRn recycling pathway for around a two-week half-life

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The following experimental conditions were applied: CE mode: CZE Electrolyte: according to PhEur Capillary: fused silica, 50 m ID, 64 -5-oxovaleriansure -L-Glutamyl-L-cysteinyl-glycin GSH, ECG [70-18-8] The method corresponds to the European Pharmacopoeia, monograph number 1670