How employers can manage the next phase of GLP-1 expansion Beyond 2026, GLP-1s are also being explored for their potential in other areas, such as cancer, addiction, and more, with rapidly changing dynamics
However, zovaglutide is years away from potential approval, has only 303 patients studied over 24 weeks, and lacks any long-term safety or cardiovascular outcomes data
Key Points: Tirzepatide (Zepbound, Mounjaro) causes diarrhea primarily because its GLP-1 component alters how food moves through your entire digestive tract
Another network meta-analysis using a Cochrane Librarybased web search found 16 randomized controlled trials used to create a frequentist network meta-analysis for people with type 2 diabetes to compare GLP1-RA (before the FLOW study, described in what follows), SGLT2i, and MRA classes compared with placebo on a background of good metabolic management and RAASi