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This absence of IGF-1 stimulation is critical for appetite neutrality because IGF-1 has known effects on hypothalamic neuropeptide expression, including alterations to neuropeptide Y (NPY) and agouti-related peptide (AgRP), both potent appetite stimulators
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SPE has many advantages over traditional methods like liquid/liquid extraction, including the use of less solvent, shorter operation time, fewer procedure steps, and lower cost [6]
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