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By reducing the electric potential at the inner mitochondrial membrane below 200 mV (negative inside), it inhibits ATP synthase (complex V) and increases the accumulation of several-fold drugs inside the mitochondria, leading to alterations in processes in the mitochondria matrix [270]

GLP-1 drugs are known to cause gastrointestinal symptoms like diarrhea or vomiting, though these effects are often mild to moderate and tend to fade over time

2025 Jan 8;17(1):14

Strategies for Accessing Medication Private purchase: The most common way to get GLP-1 medicines for weight loss in many European countries is through a private doctor