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The authors explicitly frame their own finding as relevant to the injection question: topical application, they note, "may offer an effective alternative to injection," comparing the quantity of copper made bioavailable through a realistic topical patch against a reference subcutaneous injection dose used in animal research
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Significant in the maintenance of our metabolism, blood cells, and nerve function
This case implies that the melanosis pigment-laden macrophages formed in the lamina propria of the colon pass to the regional lymph nodes and may explain the observation of similar pigment-laden macrophages in other sites
further showed that decision-making behavior in chronic pain patients exhibits significantly heightened sensitivity to punishment, with posterior insular activity strongly correlated with fatigue and pain ratings, providing direct evidence of the link between reward system dysfunction and interoceptive dysregulation (183)
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