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Basal-bolus insulin regimen When treatment with basal insulin or premixed insulins does not achieve the control goal in T2DM, the clinical practice guidelines recommend the addition of rapid-acting insulin before meals.4 Meta-analyses have not confirmed a greater hypoglycemic potency, but have reported a lower hypoglycemia rate as compared to other regimens.1517Fig

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Additionally, MASH pathomechanisms exhibit substantial inter-individual variability [24, 25], paving the way for precision medicine approaches aiming to offer the right drug to the right person at the right moment (Figure 2) [26, 27]