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Description

(2023, March 13)

Hafeman, D

Neurons provide ATP mainly through mitochondrial oxidative phosphorylation (OXPHOS), glycolysis, and patients with cognitive impairment are associated with abnormalities in cerebral glucose utilisation as well as glycolysis and OXPHOS metabolism

Unchecked lipid oxidation can stifle the response to insulin and hinder the switch from lipid to glucose metabolism following a carbohydrate meal, which is likely amplified in patients with impaired insulin sensitivity