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That is one reason the American College of Cardiology released guidance to help clinicians use weight management medications for cardiovascular benefit

Kluijtmans LAJ, Boers GHJ, Stevens EMB, Renier WO, Kraus JP, Trijbels FJM, van den Heuvel LPWJ, Blom HJ: Defective cystathionine beta-synthase regulation by S-adenosyl-methionine in a partially pyridoxine responsive homocysteinuria patient

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Evaluation of the effect of omega-3 fatty acids in the treatment of premenstrual syndrome: a pilot trial