melanotan vs melanotan 2 II MT-II Research Peptide – Peptagon Melanotan II (“Tan Jabs”): Why

Both hormones have a very short half-life (the time corresponding to a loss of half of their physiological activity), of only 1-2 minutes, in particular due to their degradation by dipeptidyl peptidase-4 (DPP-4)

A few months later, in January 1987 the group reported that the porcine peptide stimulated a small increase of insulin secretion from an isolated perfused pig pancreas and that they had observed a similar effect with a synthetic replica of the natural hormone

Murray RK, Granner DK, Mayes PA, Rodwell VR

It says these mechanisms operate in different cellular compartments and do not directly compete for clearance