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Retatrutide's path to a possible approval runs through TRIUMPH, Eli Lilly's phase 3 program of four large registrational trials enrolling more than 5,800 participants in total

This biologically locks the patient into the ecosystem, transforming a one-time prescription into a lifelong recurring revenue stream

Instead, neuronal GLP-1Rs located outside the BBB primarily serve as peripheral targets for gut-derived or pharmacologically administered GLP-1 (Varin et al., 2019

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