Likewise, only a fraction of the orally administered CoQ 10 reaches the blood while the major amount is eliminated via feces (Bentinger et al., 10 is slow and limited due to its hydrophobicity and large molecular weight and, therefore, high doses are needed to reach a number of rat tissues (e.g., muscle and brain) (Bhagavan and Chopra, 10 (Weis et al., 1994
10.1104/pp.010887 Plant Physiol
In big systematic reviews of studies that include these and higher doses, daily intake above 200mg has often shown a decrease in efficacy that researchers call a U-shaped curve.24 That means, for the average person, taking more than 200mg could potentially work against their goals
The American College of Rheumatology (ACR) recommends early aggressive therapy to prevent irreversible joint damage and achieve remission or low disease activity using a treat-to-target approach with regular monitoring of disease activity measures