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HARRISBURG Thousands of low-income Pennsylvanians will face new barriers to weight-loss drugs like Ozempic under a move quietly announced by the Shapiro administration last month thats projected to save the state hundreds of millions of dollars

Specific details regarding sample sizes and the number of replicates for each experiment are outlined in the respective figure legends

Severe (II) - less than 10% of normal enzyme activity

This contraindication reflects the theoretical concern that GLP-1 receptor stimulation could promote recurrence or progression of residual C-cell disease, even though human C-cells express minimal GLP-1 receptors