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However, notably, TMAO also exerts protective effects by activating the Nrf2 pathway, promoting Nrf2 dissociation from Keap1 and nuclear translocation, thereby inducing antioxidant genes (HO-1, NQO1, CAT) to reduce ROS accumulation and restore antioxidant enzyme activityunderscoring Nrf2s dual regulatory role in oxidative stress (Zou et al., 2024)

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Clinical studies show that GLP-1 and GIP supplements may lower fasting glucose levels in healthy subjects

10.1007/s10753-015-0140-2 127 XieT.ZhouX.WangS.LuY.ZhuH.KangA.et al (2016)