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after 14 days, 91% of treated patients showed improvement, compared with only 15% in the placebo group

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The underlying mechanisms of resistance are complex and varied, mainly involving factors such as lack of tumor immune response, depletion and loss of T-cell function, and alterations in relevant genes [118,119,120]

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PPP did not compete with ATP but interfered with phosphorylation in the activation loop of the kinase domain, in which it specifically blocked phosphorylation of the tyrosine (Y) 1136 residue, while sparing the two others (Y1131 and Y1135)

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