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found that repression of NRF2 antioxidant pathways served as a driver mechanism for the genetic premature aging disease Hutchinson-Gilford progeria syndrome (HGPS) [115], which is caused by constitutive progerin production, a mutant version of the nuclear protein lamin A

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``` If FRAT Is Positive The report helps determine whether leucovorin / folinic acid is clinically appropriate, what concerns should be considered, and what follow-up may be needed