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IGF-1 LR3s reduced affinity applies broadly across this family, which is precisely why the analog behaves as if the entire regulatory layer has been dialed down

Gonzalez, M.M

The OGDHc is particularly sensitive to lipoyl glutarylation, with ABHD11 inhibition impairing normal OGDHc catalysis and perturbing 2-oxoglutarate (2-OG) metabolism