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Persistent hurdles: heterogeneity, adaptability, and biomarker insufficiency In addition to their inherent heterogeneity and plasticity, CSCs exhibit remarkable adaptability in response to environmental pressures, including metabolic stress and therapeutic interventions

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LM, DS, VB, AM, CT, CB and FV revised the manuscript critically for important intellectual content

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The negative impact of aging on ovarian reserve, chromosome segregation, and embryonic capacity is attributed to decreased mitochondrial function and energy production (Meldrum et al., 2016)

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