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Cysteine 467 of the ASCT2 amino acid transporter is a molecular determinant of the antiport mechanism

Deficiencies in vitamin B12 can significantly affect energy levels since it is responsible for red blood cell production and oxygen transport

There are no large-scale human randomized controlled trials (RCTs) established in peer-reviewed literature as of 2026

Clinical indications include deficiency due to inadequate diet or malabsorption, drug-induced deficiency (for example, from long-term isoniazid or oral contraceptives), and certain inborn errors of metabolism (such as pyridoxine-dependent seizures or sideroblastic anemia)