By genotyping about 200 patients with prolactinomas and controls for common DRD2 polymorphisms, DA-resistance has been correlated only to a common polymorphism, a synonymous cytosine to thymine transition at position 957, a change that has been associated with susceptibility to migraine and schizophrenia, and that might alter the predicted mRNA folding, leading to a decrease in mRNA stability and translation (38)
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Guo Y, Jones D, Palmer JL, Forman A, Dakhil SR, Velasco MR, Weiss M, Gilman P, Mills GM, Noga SJ, Eng C, Overman MJ, Fisch MJ
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