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It is important to emphasise that GLP-1 agonists are not a standalone solution but should form part of a comprehensive approach including dietary modification, physical activity, and behavioural support for optimal outcomes

This differs from rare congenital leptin deficiency, a distinct condition that may respond to specific treatment with metreleptin

The dose increments are fixed to what the manufacturer programmed into the pen mechanism

Drug developers can then assess system compatibility with their drugs using robust data, giving them greater confidence during their formal primary container and autoinjector selection processes