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High-resolution approaches, including super-resolution microscopy, electron tomography, and emerging ovarian three-dimensional imaging techniques, can be applied to age-stratified ovarian samples to quantitatively map changes in mitochondria-ER, mitochondria-lysosome, mitochondria-peroxisome, and mitochondria-lipid droplet contact sites in oocytes and granulosa cells

Of note, first was the high proportion of our patients that had already tried the NHS recommended approach to losing weight

Based on these data, women who are considering becoming pregnant are now recommended to avoid using high-dose VPA by switching to other antiepileptic drugs or reducing VPA to dose to 600 mg/day or less before pregnancy (35)

Conclusions SGLT2i prescribing generally aligned with guideline-based risk profiles and demonstrated high consistency across phenotypic subgroups