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Periorbital study (28 days) : Palmitoyl pentapeptide-4 cream (0.005%) applied twice daily to the periorbital area decreased fold depth by 18%, fold thickness by 37%, and improved skin firmness by 21%

What is largely missing is the tier that decides clinical questions: randomized, controlled, blinded human trials with objective endpoints

*Correspondence: Antonio Di Sabatino, [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers