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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

Arans C, Edvardsson CE, Shevchouk OT, Zhang Q, Witley S, Blid Skldheden S, Zentveld L, Vallf D, Tufvesson-Alm M, Jerlhag E (2023) Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats

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Another unique feature is that the body produces glutathione inside cells, where it helps protect DNA, proteins, cell membranes, and mitochondria from oxidative damage