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Methods Experimental model Commercial primary cells from human knees, Normal Human Articular Knee Chondrocytes (NHAC-Kn), were obtained from Lonza (USA) and cultured in DMEM-F12/Hams medium (#11320033
For type 2 diabetes, options include metformin (typically first-line), SGLT2 inhibitors, DPP-4 inhibitors, or insulin therapy
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In practice, simultaneous application is problematic: a 2022 Journal of Cosmetic Dermatology study found that applying both at the same time increased transepidermal water loss by 41% and produced 3.2 times more self-reported stinging compared to staggered application
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