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doi: 10.3389/fendo.2022.810242 Received 06 November 2021 Accepted 24 January 2022 Published 21 February 2022 Volume 13 - 2022 Edited by Davor Jezek, University of Zagreb, Croatia Reviewed by Gian Maria Busetto, University of Foggia, Italy

However, when levels of cholesterol in the blood become imbalanced, it can lead to atherosclerosis, a condition where plaque builds up in your arteries, leading to heart disease

Tirzepatide's GIPR agonism in fat cells increases cAMP-driven lipolysis, reduces fatty acid re-esterification, and promotes adipocyte differentiation toward a smaller, more metabolically favorable phenotype [7]

Group SA (Rhinosinusitis+amlodipine) this group was similar to Group C than the other experimental groups