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First, they suggest that AOD-9604 can be used for extended periods without loss of efficacy due to antibody neutralization

"Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans"

Regarding the potential role of oxidative processes in the escape phenomenon, it is suggested that the generation of ROS [115,116,117] is responsible for NIS downregulation resulting from exposure to iodine excess [110] (see also the subsections In vitro studies and In vivo studies)

This link between cysteine-oxidative catabolism-derived pyruvate and cancer has been described in pancreatic cancer 73 and non-small lung cancer cells, 69 although additional studies that focus on other cancer types are required to strengthen this association