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Commenters further stated that even absent circularity, the MA negotiated rates cannot assist with determining when changes to the MS-DRG classification system itself are necessary (for example splitting MS-DRGs) because unlike the current case-level methodology the MA negotiated rates do not provide information on resource use variations within an MS-DRG

While the primary goal is to boost NAD+ levels, this cascade could theoretically lead to unforeseen interactions with other metabolic pathways or even pharmacological agents being studied concurrently

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