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It can curtail the transcription of SLC7A11, influencing System Xc-'s activity [65]

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GLP-1 receptor agonists exert their therapeutic effects through several mechanisms : they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the hypothalamus to promote satiety and reduce food intake

This dual action amplifies the neurotrophic signaling cascade, potentially producing more robust effects than compounds that influence only one component of the pathway