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Administration of liraglutide, still at nanomolar concentrations, to bone marrow macrophages or the pre-osteoclast Raw264.7 cell line resulted in a reduction in osteoclast formation and osteoclast-mediated resorption [53], suggesting a decoupling effect on bone formation and resorption
Real-world response will likely be more variable due to differences in dose tolerance, adherence, and individual metabolic factors
This is one of the most common reasons people transition from liraglutide to tirzepatide
25,26 Effects on Epicardial Adipose Tissue GLP1-RAs decrease the volume of epicardial adipose tissue, which is often elevated in HFpEF and is a source of proinflammatory cytokines and adipokines
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