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The body only produces relatively small quantities of TUDCA, which can be negatively impacted by factors such as poor diet, microbiome dysbiosis (parasites, pathogens etc), gallbladder dysfunction, certain medications and impaired liver function

Despite the undeniable success of the GLP-1 analogues, there remains a gap between the efficacy of GLP-1 analogues and that of bariatric surgery

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No sample size calculation was performed for any study, however, for all studies, we typically start with an n = 10, which is usually sufficient to see statistically different changes between the groups, as well as a sufficient sample size for subsequent analyses on tissues and serum