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You can get pernicious anemia if: You have an autoimmune disease that makes your immune system attack the cells in your stomach that produce intrinsic factor, a protein that helps your body absorb B12

Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)

Its important to note that for individuals with adequate vitamin B12 levels, there is limited scientific evidence that B12 injections alone will enhance skin hydration or appearance