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At the same time, CE-MS can effectively analyze polar and charged metabolites (Zhang and Ramautar, 2020)

In this context, collected data are presented to manifest that sulfonylureas are capable of impacting other ion channels besides K ATP channels, such as TRP and BK Ca , via direct and indirect ways, exhibiting the involvement of diverse ion channels in the modulation of insulin secretion and antidiabetic actions (see Table 1)

SCFAs activate PPAR and favor adiponectin secretion, improving insulin sensitivity and dampening inflammatory tone (233)

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