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23 These symptoms can be severe in some patients, resulting in a pause of dose escalation, and if intolerable GI symptoms continue, a dose adjustment to the previous lower dose or a switch to an alternative GLP-1 RA should be considered

Unlike semaglutide (GLP-1 only) or tirzepatide (GLP-1 + GIP), Retatrutide adds glucagon receptor agonism, making it a triple agonist with distinct pharmacological properties under study

Though the trial was powered to only detect non-inferiority, the observed (non-significant) hazard ratio for semaglutide vs

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