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Polyethylenimine (PEI) NPs delivering GLP-1 genes have improved -cell function and endogenous insulin secretion, and combined nanoparticle systems delivering insulin and GLP-1 agonist genes exhibited synergistic improvements in glycaemic control [219, 220]
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Large proportions, 35% and 55% of the patients in the semaglutide 0.5 and 1.0 mg groups, respectively, achieved a clinically meaningful weight loss of 5% or more, an important factor in T2D treatment associated with a multitude of beneficial physiological effects including improved glycaemic control
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