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Author contributions GKS: Conceptualization, Formal Analysis, Methodology, Supervision, Visualization, Writing original draft, Writing review & editing, Resources

594 The OPTION-DM study determined which monotherapy and combination therapy of amitriptyline, duloxetine, and pregabalin are the most clinically efficacious

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Although previous definitions of an AI are somewhat debated due to the underestimation of continuous production, recent ESE/ENSAT practice guideline [8] proposed the term mild autonomous cortisol secretion (MACS) for all patients with a non-suppressed overnight 1 mg dexamethasone suppression test cortisol (F) above 50nmol/l