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Novo Nordisk and Eli Lilly are already accelerating efforts to expand manufacturing capacity and develop new formulations, including oral therapies, while numerous late entrants are pursuing oral obesity treatments and next-generation GLP-1 drugs

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These experiments confirmed that GRK2 is indeed recruited to the WT receptor downstream of GLP-1 stimulation and identified the third serine doublet at position 451/452, but not the other two doublets, as required for the recruitment of GRK2 to GLP-1-stimulated GLP-1R in our -cell line (Fig