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Increased erythrocyte oxidative stress results in the opening of multiple ion channels, comprising the nonselective cation channels (NSCC), like sodium, potassium, and calcium channels [202, 404]

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The biological footprint of GHK-Cu in the published research includes copper-dependent extracellular matrix processes (notably through the copper-dependent enzyme lysyl oxidase, which cross-links collagen and elastin), broad effects on gene expression characterized in transcriptomic studies, antioxidant and redox-related effects connected to copper biochemistry, effects in wound-healing and tissue-repair research models, and effects in hair follicle biology research