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Endocrinology,2010;151(9): 4187

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142 PetreB.MorinE.TisserantE.HacquardS.Da SilvaC.PoulainJ.et al (2012)

However, in individuals predisposed to PEM, due to underlying pathological conditions (e.g., sequelae of viral infections), this adaptive process is disrupted, preventing effective restoration of mitochondrial homeostasis and may initiate a potential vicious cycle of dysfunction