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These findings suggest that TMAOs effects on metabolic function are contingent on specific contexts

Affordability and Access Perhaps the most striking finding is the financial barrier

In a 2025 review, after 1,200 mg intravenously twice a week for six weeks, 37.5% of participants reported lighter skin compared with 18.7% in the placebo group, and the effect faded after about six months

This finding could be explained by a competition among selenoproteins for available selenium in the form of selenocysteine required for biosynthesis of the selenoproteins and for the selenium-incorporation machinery