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However, as you move to a higher dose or as your body becomes more accustomed to the medication, the appetite-suppressing effects tend to become more pronounced, reducing hunger and cravings to a greater extent

Global Burden of Disease 2021: Findings from the GBD 2021 Study.Seattle, WA: IHME

Studies using GIP-Cre mice have demonstrated that GIP receptors are expressed in key brain regions involved in feeding regulation, including the ARC, paraventricular nucleus (PVN), and DMH of the hypothalamus, as well as the area postrema (AP) of the medulla [31]